Cox proportional threats habits were utilized in order to imagine RRs and you may 95% CIs

RRs (95% CI) regarding complete, ischemic, and hemorrhagic shots by quintiles regarding joint eating plan scores to possess magnesium, potassium, and you may calcium supplements intakes for the 86,149 ladies in new NHS I and you will 94,715 women in this new NHS II step 1

I updated the new meta-analyses out-of potential degree regarding weightloss magnesium ( 21), potassium ( 22), and calcium supplements ( 23) intakes and you will danger of coronary attack

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

RRs (95% CI) out of full, ischemic, and you can hemorrhagic strokes because of the quintiles regarding combined eating plan scores to possess magnesium, potassium, and you will calcium consumption in the 86,149 women in the fresh NHS I and you will 94,715 women in this new NHS II step one

We upgraded the new meta-analyses off potential training from fat loss magnesium ( 21), potassium ( 22), and you will calcium ( 23) consumption and likelihood of stroke

The multivariate model was adjusted for age, calendar year, total calories (quintiles of kcal), BMI (in kg/m 2 ; <25, 25 to <30, or ?30), parental history of heart disease (aged ?60 y), alcohol intake (0, 0 to <5, 5 to <10, 10 to <15, or ?15 g/d), physical activity (<3, 3 to <9, 9 to <18, 18 to <27, or ?27 metabolic equivalent tasks/wk), smoking, postmenopausal hormone therapy, oral contraceptive use (never, past, or current), menopausal status (premenopausal or postmenopausal), aspirin (0 to <2 or ?2 pills/wk), multivitamin, history of hypertension, hypercholesterolemia, diabetes at baseline, and thiazide use (yes or no). NHS, Nurses' Health Study.

We examined separately the relation between intakes of magnesium, potassium, and calcium from supplements and risk of stroke. There was no significant association between supplemental magnesium or calcium intake and risk of total, ischemic, or hemorrhagic stroke in the pooled analyses. We observed a significant inverse association between supplemental potassium intake and risk of ischemic but not total or hemorrhagic stroke. The pooled multivariate RR for comparison of highest with lowest quintiles of supplemental potassium intake was 0.71 (95% CI: 0.56, 0.89, P-trend < 0.01) for ischemic stroke. Pooled multivariate RRs for supplemental magnesium (Supplemental Table 7), supplemental potassium (Supplemental Table 8), and supplemental calcium (Supplemental Table 9) and risk of total, ischemic, and hemorrhagic strokes are shown in the supplemental material.

I examined total and slimming down intakes of each mineral and you may chance out-of coronary arrest to choose any potential nonlinear organization by using minimal cubic splines; although not, zero high departure off linearity was Sports Sites dating observed. At the same time, i explored the possibility effect modification by many years, blood circulation pressure, otherwise all forms of diabetes on relatives between total intake of the many step three nutrition and you will chance of overall coronary attack. Zero extreme impact modification is actually noticed by this type of facts.

Prior meta-analyses incorporated comes from prior analyses throughout the NHS ( 10); such results was basically changed from the leads to the modern studies. On the other hand, the latest literature is seemed, and you will recent possible knowledge ( 8, 24) had been included in this type of upgraded meta-analyses. Zero ranging from-training heterogeneity try noticed for your of step three vitamins. This new combined RR regarding full coronary attack was 0.87 (95% CI: 0.83, 0.92) having a 100-mg/d boost from magnesium consumption, 0.91 (95% CI: 0.88, 0.94) having a great one thousand-mg/d increase from potassium intake, and you can 0.98 (95% CI: 0.94, 1.02) to have a 3 hundred-mg/d increase out of calcium supplements consumption.